Article

A topology-dependent IRE1α signaling axis generates a cryptic XBP1 isoform present in human cancers

2026-06-04

Abstract excerpt

<title>Abstract</title> <p>IRE1α, the most conserved unfolded protein response sensor, is displaced from the ER during caspase-mediated cleavage, viral infection, and chronic stress, but the signaling consequences are unknown. Using optogenetic IRE1α constructs targeted to either the ER or the cytoplasm, we show that subcellular topology determines oligomerization dynamics, transcriptional output, and cell fate....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f9414fc7-7315-58bd-8bc2-123423ce6044
DOI: 10.21203/rs.3.rs-9695931/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A topology-dependent IRE1α signaling axis generates a cryptic XBP1 isoform present in human cancersDOI 10.21203/rs.3.rs-9695931/v1Read

Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum StressSemantic proximity Read

Noncanonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α promotes cancer-cell survivalSemantic proximity Read

The UPRosome – decoding novel biological outputs of IRE1α functionSemantic proximity Read

Optogenetic Clustering of Human IRE1 Reveals Differential Regulation of Transcription and mRNA Splice Isoform Abundance by the UPRSemantic proximity Read

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors.Semantic proximity Read

A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α–XBP1 ActivationSemantic proximity Read

Genome-Wide mRNA Profiling Identifies X-Box-Binding Protein 1 (XBP1) As An IRE1 And PUMA RepressorSemantic proximity Read

SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cellsSemantic proximity Read

How IRE1 Reacts to ER StressSemantic proximity Read

BAX inhibitor‐1: between stress and survivalSemantic proximity Read

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell FatesSemantic proximity Read

The multiple roles of the unfolded protein response regulator IRE1α in cancerSemantic proximity Read