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Article

The nonsense-mediated RNA decay pathway is disrupted in inflammatory myofibroblastic tumors.

The Journal of clinical investigation - 1 Aug 2016

Lu JingWei, Plank Terra-Dawn, Su Fang, Shi XiuJuan, Liu Chen, Ji Yuan, Li ShuaiJun, Huynh Andrew, Shi Chao, Zhu Bo, Yang Guang, Wu YanMing, Wilkinson Miles F, Lu YanJun

Abstract excerpt

Inflammatory myofibroblastic tumors (IMTs) are characterized by myofibroblast proliferation and an inflammatory cell infiltrate. Little is known about the molecular pathways that precipitate IMT formation. Here, we report the identification of somatic mutations in UPF1, a gene that encodes an essential component of the nonsense-mediated RNA decay (NMD) pathway, in 13 of 15 pulmonary IMT samples. The majority of...

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Identifiers

PMID: 27348585
DOI: 10.1172/JCI86508
PMCID: PMC4966300

Genes

UPF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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