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Article

The landscape of genetic alterations of UVB-induced skin tumors in DNA repair-deficient mice.

Experimental dermatology - 1 Oct 2022

Yoshioka Ai, Nakaoka Hirofumi, Fukumoto Takeshi, Inoue Ituro, Nishigori Chikako, Kunisada Makoto

Abstract excerpt

Non-melanoma skin cancer (NMSC) is mainly caused by ultraviolet (UV)-induced somatic mutations and is characterized by UV signature modifications. Xeroderma pigmentosum group A (Xpa) knockout mice exhibit extreme UV-induced photo-skin carcinogenesis, along with a photosensitive phenotype. We performed whole-exome sequencing (WES) of squamous cell carcinoma (SCC) samples after repetitive ultraviolet B (UVB)...

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Identifiers

PMID: 35751582
DOI: 10.1111/exd.14634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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