A Pan-Cancer Study of Somatic TERT Promoter Mutations and Amplification in 30,773 Tumors Profiled by Clinical Genomic Sequencing.

doi:10.1016/j.jmoldx.2020.11.003

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Article

A Pan-Cancer Study of Somatic TERT Promoter Mutations and Amplification in 30,773 Tumors Profiled by Clinical Genomic Sequencing.

The Journal of molecular diagnostics : JMD - 1 Feb 2021

Gupta Sounak, Vanderbilt Chad M, Lin Yun-Te, Benhamida Jamal K, Jungbluth Achim A, Rana Satshil, Momeni-Boroujeni Amir, Chang Jason C, Mcfarlane Tiffany, Salazar Paulo, Mullaney Kerry, Middha Sumit, Zehir Ahmet, Gopalan Anuradha, Bale Tejus A, Ganly Ian, Arcila Maria E, Benayed Ryma, Berger Michael F, Ladanyi Marc, Dogan Snjezana

Abstract excerpt

TERT gene promoter mutations are known in multiple cancer types. Other TERT alterations remain poorly characterized. Sequencing data from 30,773 tumors analyzed by a hybridization capture next-generation sequencing assay (Memorial Sloan Kettering Cancer Center Integrated Mutation Profiling of Actionable Cancer Targets) were analyzed for the presence of TERT alterations. Promoter rearrangements (500 bases upstream...

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Identifiers

PMID: 33285287
DOI: 10.1016/j.jmoldx.2020.11.003
PMCID: PMC7874333

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