Article
Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations.
Nature communications - 14 Oct 2020
Brady Samuel W, Liu Yanling, Ma Xiaotu, Gout Alexander M, Hagiwara Kohei, Zhou Xin, Wang Jian, Macias Michael, Chen Xiaolong, Easton John, Mulder Heather L, Rusch Michael, Wang Lu, Nakitandwe Joy, Lei Shaohua, Davis Eric M, Naranjo Arlene, Cheng Cheng, Maris John M, Downing James R, Cheung Nai-Kong V, Hogarty Michael D, Dyer Michael A, Zhang Jinghui
Abstract excerpt
Neuroblastoma is a pediatric malignancy with heterogeneous clinical outcomes. To better understand neuroblastoma pathogenesis, here we analyze whole-genome, whole-exome and/or transcriptome data from 702 neuroblastoma samples. Forty percent of samples harbor at least one recurrent driver gene alteration and most aberrations, including MYCN, ATRX, and TERT alterations, differ in frequency by age. MYCN alterations...
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