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Article

Telomerase Is a Prognostic Marker of Poor Outcome and a Therapeutic Target in Neuroblastoma

16 Sept 2019

Abstract excerpt

PURPOSE Telomere maintenance is a hallmark of high-risk neuroblastoma; however, the contribution of telomerase and alternative lengthening of telomeres (ALT) to clinical phenotypes has remained unclear. We aimed to determine the clinical relevance of telomerase activation versus ALT as biomarkers in pretreatment neuroblastoma and to assess the potential value of telomerase as a therapeutic target. MATERIALS AND...

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PMID: 35100718
DOI: 10.1200/po.19.00072

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