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Article

RAS mutations and colorectal cancer metabolism: a metabolomic analysis of tissue samples.

BMC cancer - 14 Oct 2025

Li Jianjiong, Dong Buyuan

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is the third most common cancer globally, with incidence and mortality rates projected to rise significantly by 2040. RAS mutations are prevalent in CRC and associated with poor prognosis, yet their role in early-stage CRC remains debated. Metabolomics has revealed metabolic profile differences between CRC patients and healthy individuals, as well as between RAS-mutant and...

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Identifiers

PMID: 41088034
DOI: 10.1186/s12885-025-14994-0
PMCID: PMC12522339

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