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Article

Regulation of the metabolite profile by an APC gene mutation in colorectal cancer.

Cancer science - 1 Jun 2012

Yoshie Tomoo, Nishiumi Shin, Izumi Yoshihiro, Sakai Aya, Inoue Jun, Azuma Takeshi, Yoshida Masaru

Abstract excerpt

Mutation of the APC gene occurs during the early stages of colorectal cancer development. To obtain new insights into the mechanisms underlying the aberrant activation of the Wnt pathway that accompanies APC mutation, we carried out a gas chromatography-mass spectrometry-based semiquantitative metabolome analysis. In vitro experiments comparing SW480 cells expressing normal APC and truncated APC indicated that...

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Identifiers

PMID: 22380946
DOI: 10.1111/j.1349-7006.2012.02262.x
PMCID: PMC7685086

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APC

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