Article

Combination of Artesunate and WNT974 Induces KRAS Protein Degradation by Upregulating E3 Ligase ANACP2 and β-TrCP in the Ubiquitin–Proteasome Pathway

2021-10-01

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>KRAS mutation is one of the dominant gene mutations in colorectal cancer (CRC). Up to present, targeting KRAS for CRC treatment remains a clinical challenge. WNT974 (LGK974) is a porcupine inhibitor that interferes Wnt signaling pathway. Artesunate (ART) is a water-soluble semi-synthetic derivative of artemisinin.<bold>Methods</bold>The synergistic effect of ART a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 952b6588-6e68-568f-a60f-efb0ae590b80
DOI: 10.21203/rs.3.rs-744967/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Combination of Artesunate and WNT974 Induces KRAS Protein Degradation by Upregulating E3 Ligase ANACP2 and β-TrCP in the Ubiquitin–Proteasome PathwayDOI 10.21203/rs.3.rs-744967/v2Read

Artesunate inhibits intestinal tumorigenesis through inhibiting wnt signaling.Semantic proximity Read

Colon cancer cells evade drug action by enhancing drug metabolismSemantic proximity Read

Aspirin Synergizes with Regorafenib to Reduce Growth of Colorectal CancerSemantic proximity Read

Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells.Semantic proximity Read

The rational modulation of autophagy sensitizes colorectal cancer cells to 5-fluouracil and OxaliplatinSemantic proximity Read

WNT signalling promotes NF-κB activation and drug resistance in KRAS-mutant colorectal cancer.Semantic proximity Read

Niclosamide is a potential therapeutic for familial adenomatosis polyposis by disrupting Axin-GSK3 interactionSemantic proximity Read

Synergistic Effects of Combined Wnt/KRAS Inhibition in Colorectal Cancer CellsSemantic proximity Read

CYP26A1 Links WNT and Retinoic Acid Signaling: A Target to Differentiate ALDH+ Stem Cells in APC-Mutant CRCSemantic proximity Read

Cancer Cell Resistance to Aurora Kinase Inhibitors: Identification of Novel Targets for Cancer TherapySemantic proximity Read

Heteronemin and Tetrac Induce Anti-Proliferation by Blocking EGFR-Mediated Signaling in Colorectal Cancer Cells.Semantic proximity Read

Effect of casein kinase 1α inhibition on autophagy flux and the AKT/phospho-β-catenin (S552) axis in HCT116, a RAS-mutated colorectal cancer cell line.Semantic proximity Read