Article

Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target

2023-03-12

Abstract excerpt

With colorectal cancer (CRC) being the second most common cause of cancer-related deaths worldwide 1 , there is an urgent need for better diagnostic tools and new, more targeted therapies. Here we used genetically engineered mouse models (GEMMs), and multimodal mass spectrometry-based metabolomics to study the impact of common genetic drivers of CRC on the metabolic landscape of the intestine. We show that unsupe...

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Literature Corpus work: 0a90dfdf-1c82-577f-ab60-f5d10f7beb42
DOI: 10.1101/2023.03.12.531945

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