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Exact site frequency spectra of neutrally evolving tumors: A transition between power laws reveals a signature of cell viability.

Theoretical population biology - 1 Dec 2021

Gunnarsson Einar Bjarki, Leder Kevin, Foo Jasmine

Abstract excerpt

The site frequency spectrum (SFS) is a popular summary statistic of genomic data. While the SFS of a constant-sized population undergoing neutral mutations has been extensively studied in population genetics, the rapidly growing amount of cancer genomic data has attracted interest in the spectrum of an exponentially growing population. Recent theoretical results have generally dealt with special or limiting...

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PMID: 34560155
DOI: 10.1016/j.tpb.2021.09.004

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