Article

Numbers of mutations within multicellular bodies: why it matters

2022-09-27

Abstract excerpt

Multicellular organisms often start life as a single cell. Subsequent cell division builds the body. Each mutational event during those developmental cell divisions carries forward to all descendant cells. The overall number of mutant cells in the body follows the Luria–Delbrück process. This article first reviews the basic quantitative principles by which one can understand the likely number of mutant cells and t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 23d4c584-3a66-5e35-93fa-e9e69476e32e
DOI: 10.1101/2022.09.26.509555

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Numbers of mutations within multicellular bodies: why it mattersDOI 10.1101/2022.09.26.509555Read

Evolution in health and medicine Sackler colloquium: Somatic evolutionary genomics: mutations during development cause highly variable genetic mosaicism with risk of cancer and neurodegeneration.Semantic proximity Read

A model for postzygotic mosaicisms quantifies the allele fraction drift, mutation rate, and contribution to de novo mutations.Semantic proximity Read

Somatic Mosaicism in Biology and Disease.Semantic proximity Read

Human embryonic genetic mosaicism and its effects on development and disease.Semantic proximity Read

Spatial population structure can reverse the dependence of mutant burden on the death-to-birth ratio of cellsSemantic proximity Read

Muller’s ratchet as a mechanism of frailty and multimorbiditySemantic proximity Read

Pathogenic Mechanisms of Somatic Mutation and Genome Mosaicism in Aging.Semantic proximity Read

Somatic mutations impose an entropic upper bound on human lifespanSemantic proximity Read

Mutation rates and fitness consequences of mosaic chromosomal alterations in blood.Semantic proximity Read

Somatic mosaicism and cancer: inference based on a conditional Luria-Delbrück distribution.Semantic proximity Read

Genome sequencing of normal cells reveals developmental lineages and mutational processes.Semantic proximity Read

The Implications of Small Stem Cell Niche Sizes and the Distribution of Fitness Effects of New Mutations in Aging and TumorigenesisSemantic proximity Read