Targeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype.

doi:10.1038/s41467-025-61092-7

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Article

Targeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype.

Nature communications - 4 Jul 2025

Lou Song, DJiake Tihagam Rachisan, Wasko Urszula N, Equbal Zaffar, Venkatesan Sanjay, Braczyk Klaudia, Przanowski Piotr, Il Koo Bon, Saltani Ilyas, Singh Arjun Tushir, Likhite Shibi, Powers Samantha, Souza George M P R, Maxwell Robert A, Yu Jun, Zhu Lihua J, Beenhakker Mark, Abbott Stephen B G, Lu Zhipeng, Green Michael R, Meyer Kathrin C, Tushir-Singh Jogender, Bhatnagar Sanchita

Abstract excerpt

X chromosome inactivation (XCI) is induced by Xist long non-coding RNA and protein-coding genes. However, the role of small non-coding RNA function in XCI remains unidentified. Our genome-wide, loss-of-function CRISPR/Cas9 screen in female fibroblasts identified microRNAs (miRNAs) as regulators of XCI. A striking finding is the identification of miR106a among the top candidates from the screen. Loss of miR106a is...

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Identifiers

PMID: 40615387
DOI: 10.1038/s41467-025-61092-7
PMCID: PMC12227778

Genes

MECP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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