Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons.

Science translational medicine - 18 Jan 2023

Qian Junming, Guan Xiaonan, Xie Bing, Xu Chuanyun, Niu Jacqueline, Tang Xin, Li Charles H, Colecraft Henry M, Jaenisch Rudolf, Liu X Shawn

Abstract excerpt

Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by loss-of-function heterozygous mutations of methyl CpG-binding protein 2 (MECP2) on the X chromosome in young females. Reactivation of the silent wild-type MECP2 allele from the inactive X chromosome (Xi) represents a promising therapeutic opportunity for female patients with RTT. Here, we applied a multiplex epigenome editing approach to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenome
Share to Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methyl-CpG-Binding Protein 2

Share to Mixed Function Oxygenases

Share to Mutation

Share to Neurons

Share to Proto-Oncogene Proteins

Share to Rett Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 36652535
DOI: 10.1126/scitranslmed.add4666
PMCID: PMC11975455

Genes

MECP2
CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons.PMID 36652535Read ↗

Multiplex Epigenome Editing of <i>MECP2</i> to Rescue Rett Syndrome NeuronsSemantic proximity Read ↗

State-of-the-art therapies for Rett syndrome.Semantic proximity Read ↗

Epigenome editing of MECP2 rescues Rett syndrome neurons.Semantic proximity Read ↗

Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations.Semantic proximity Read ↗

Selective Xi reactivation and alternative methods to restore MECP2 function in Rett syndrome.Semantic proximity Read ↗

Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function.Semantic proximity Read ↗

MECP2 Dysfunction in Rett Syndrome: Molecular Mechanisms, Multisystem Pathology, and Emerging Therapeutic Strategies.Semantic proximity Read ↗

Pharmacological reactivation of inactive X-linked Mecp2 in cerebral cortical neurons of living mice.Semantic proximity Read ↗

Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated <i>MECP2</i> mutationsSemantic proximity Read ↗

Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation.Semantic proximity Read ↗

Transcriptional regulation in pluripotent stem cells by methyl CpG-binding protein 2 (MeCP2).Semantic proximity Read ↗

Generation and Characterization of a Human Neuronal In Vitro Model for Rett Syndrome Using a Direct Reprogramming Method.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.