Article

Reactivation of the X-linked <i>Nexmif</i> Gene Corrects Mosaic NEXMIF Deficiency in Heterozygous Female Mice

2025-12-01

Abstract excerpt

We have previously demonstrated that heterozygous (HET) female mice lacking one copy of the X-linked gene Nexmif display autistic-like phenotypes, memory impairments, and deficits in synapse and neuron morphology. Due to random X Chromosome Inactivation (XCI), the HET mouse brain contains two populations of neurons: NEXMIF-expressing cells (wildtype, WT) and NEXMIF-lacking cells (knockout, KO). Interestingly, bec...

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Literature Corpus work: 3ed4ef4e-cde2-5cf0-930b-ec4b72f33e6d
DOI: 10.1101/2025.11.29.691251

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