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Article

Selective Xi reactivation and alternative methods to restore MECP2 function in Rett syndrome.

Trends in genetics : TIG - 1 Sept 2022

Grimm Niklas-Benedikt, Lee Jeannie T

Abstract excerpt

The human X-chromosome harbors only 4% of our genome but carries over 20% of genes associated with intellectual disability. Given that they inherit only one X-chromosome, males are more frequently affected by X-linked neurodevelopmental genetic disorders than females. However, despite inheriting two X-chromosomes, females can also be affected because X-chromosome inactivation enables only one of two X-chromosomes...

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Share to Chromosomes, Human, X
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Share to Methyl-CpG-Binding Protein 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35248405
DOI: 10.1016/j.tig.2022.01.007
PMCID: PMC9915138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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