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Deep stratification by transcriptome molecular characters for precision treatment of patients with systemic lupus erythematosus

28 Oct 2022

Abstract excerpt

OBJECTIVES: To leverage the high clinical heterogeneity of systemic lupus erythematosus (SLE), we developed and validated a new stratification scheme by integrating genome-scale transcriptomic profiles to identify patient subtypes sharing similar transcriptomic markers and drug targets. METHODS: A normalized compendium of transcription profiles was created from peripheral blood mononuclear cells (PBMCs) of 1046...

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PMID: 36308437
DOI: 10.1093/rheumatology/keac625

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