Article
High Persister Mutants in Mycobacterium tuberculosis.
PloS one - 1 Jan 2016
Torrey Heather L, Keren Iris, Via Laura E, Lee Jong Seok, Lewis Kim
Abstract excerpt
Mycobacterium tuberculosis forms drug-tolerant persister cells that are the probable cause of its recalcitrance to antibiotic therapy. While genetically identical to the rest of the population, persisters are dormant, which protects them from killing by bactericidal antibiotics. The mechanism of persister formation in M. tuberculosis is not well understood. In this study, we selected for high persister (hip)...
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