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Article

Isolation of mitochondrial mutation-specific T cell receptors.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2025

Kirkpatrick Catherine, Hao Shanshan, Quick Charles M, Post Steven R, Leung Yuet-Kin, Burdine Lyle, Lu Yong-Chen William

Abstract excerpt

Neoantigen-specific T cells play a major role in cancer immunotherapy. Mutated proteins derived from non-synonymous mutations in tumor genomic DNA are the major source of neoantigens. It is conceivable that non-synonymous mutations found in tumor mitochondrial DNA (mtDNA) can also generate neoantigens that can be recognized by T cell receptors (TCRs). However, no tumor mitochondrial mutation-specific TCRs have...

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Share to Antigens, Neoplasm
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to HLA-A2 Antigen

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Share to Receptors, Antigen, T-Cell

Source

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Identifiers

PMID: 40587813
DOI: 10.1093/jimmun/vkaf139
PMCID: PMC12576121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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