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Article

An Efficient Single-Cell RNA-Seq Approach to Identify Neoantigen-Specific T Cell Receptors.

Molecular therapy : the journal of the American Society of Gene Therapy - 7 Feb 2018

Lu Yong-Chen, Zheng Zhili, Robbins Paul F, Tran Eric, Prickett Todd D, Gartner Jared J, Li Yong F, Ray Satyajit, Franco Zulmarie, Bliskovsky Valery, Fitzgerald Peter C, Rosenberg Steven A

Abstract excerpt

The adoptive transfer of neoantigen-reactive tumor-infiltrating lymphocytes (TILs) can result in tumor regression in patients with metastatic cancer. To improve the efficacy of adoptive T cell therapy targeting these tumor-specific mutations, we have proposed a new therapeutic strategy, which involves the genetic modification of autologous T cells with neoantigen-specific T cell receptors (TCRs) and the transfer...

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Share to Antigens, Neoplasm
Share to High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocytes, Tumor-Infiltrating

Share to Proto-Oncogene Proteins p21(ras)

Share to Receptors, Antigen, T-Cell

Share to Single-Cell Analysis

Share to T-Cell Antigen Receptor Specificity

Share to T-Lymphocytes

Source

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Identifiers

PMID: 29174843
DOI: 10.1016/j.ymthe.2017.10.018
PMCID: PMC5835023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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