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Article

Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor.

Cancer immunology research - 2 Sept 2016

Pasetto Anna, Gros Alena, Robbins Paul F, Deniger Drew C, Prickett Todd D, Matus-Nicodemos Rodrigo, Douek Daniel C, Howie Bryan, Robins Harlan, Parkhurst Maria R, Gartner Jared, Trebska-McGowan Katarzyna, Crystal Jessica S, Rosenberg Steven A

Abstract excerpt

Adoptive transfer of T cells with engineered T-cell receptor (TCR) genes that target tumor-specific antigens can mediate cancer regression. Accumulating evidence suggests that the clinical success of many immunotherapies is mediated by T cells targeting mutated neoantigens unique to the patient. We hypothesized that the most frequent TCR clonotypes infiltrating the tumor were reactive against tumor antigens. To...

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Share to Antigens, Neoplasm
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clonal Evolution

Share to Immunophenotyping

Share to Lymphocyte Count

Share to Lymphocytes, Tumor-Infiltrating

Share to Receptors, Antigen, T-Cell

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Source

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Identifiers

PMID: 27354337
DOI: 10.1158/2326-6066.CIR-16-0001
PMCID: PMC5010958

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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