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Article

Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2017

Parkhurst Maria, Gros Alena, Pasetto Anna, Prickett Todd, Crystal Jessica S, Robbins Paul, Rosenberg Steven A

Abstract excerpt

Purpose: The adoptive transfer of lymphocytes genetically modified to express tumor reactive T-cell receptors (TCR) can mediate tumor regression. Some tumor-infiltrating lymphocytes (TIL) recognize somatic mutations expressed only in the patient's tumors, and evidence suggests that clinically effective TILs target tumor-specific neoantigens. Here we attempted to isolate neoantigen-reactive TCRs as a prelude to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

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Share to Receptors, Antigen, T-Cell

Source

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Identifiers

PMID: 27827318
DOI: 10.1158/1078-0432.CCR-16-2680
PMCID: PMC6453117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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