Article

Dual-degenerate TCRs target multiple KRAS hotspot and HLA-A3 family combinations

2026-06-19

Abstract excerpt

<title>Abstract</title> <p>Oncogenic KRAS mutations drive a substantial proportion of lung cancers and are linked to poor prognosis, positioning KRAS as a compelling target for cellular immunotherapy. Thirty-five percent of lung adenocarcinomas harbor the KRAS G12C, G12V, G12D mutations. Here, we developed HLA-A*03:01- and HLA-A*11:01-restricted T cell receptors (TCR) targeting the most prevalent G12C and G12V KR...

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Literature Corpus work: 00621163-83b9-52e6-93d5-ff46b50c0e42
DOI: 10.21203/rs.3.rs-10030408/v1

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