Article
Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing.
Nature - 27 Nov 2014
Yadav Mahesh, Jhunjhunwala Suchit, Phung Qui T, Lupardus Patrick, Tanguay Joshua, Bumbaca Stephanie, Franci Christian, Cheung Tommy K, Fritsche Jens, Weinschenk Toni, Modrusan Zora, Mellman Ira, Lill Jennie R, Delamarre Lélia
Abstract excerpt
Human tumours typically harbour a remarkable number of somatic mutations. If presented on major histocompatibility complex class I molecules (MHCI), peptides containing these mutations could potentially be immunogenic as they should be recognized as 'non-self' neo-antigens by the adaptive immune system. Recent work has confirmed that mutant peptides can serve as T-cell epitopes. However, few mutant epitopes have...
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