Article
Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes.
The Journal of clinical investigation - 1 Oct 2015
Cohen Cyrille J, Gartner Jared J, Horovitz-Fried Miryam, Shamalov Katerina, Trebska-McGowan Kasia, Bliskovsky Valery V, Parkhurst Maria R, Ankri Chen, Prickett Todd D, Crystal Jessica S, Li Yong F, El-Gamil Mona, Rosenberg Steven A, Robbins Paul F
Abstract excerpt
Adoptively transferred tumor-infiltrating T lymphocytes (TILs) that mediate complete regression of metastatic melanoma have been shown to recognize mutated epitopes expressed by autologous tumors. Here, in an attempt to develop a strategy for facilitating the isolation, expansion, and study of mutated antigen-specific T cells, we performed whole-exome sequencing on matched tumor and normal DNA isolated from 8...
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