Human Blood CD1c+ Dendritic Cells Encompass CD5high and CD5low Subsets That Differ Significantly in Phenotype, Gene Expression, and Functions.

doi:10.4049/jimmunol.1600193

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Article

Human Blood CD1c+ Dendritic Cells Encompass CD5high and CD5low Subsets That Differ Significantly in Phenotype, Gene Expression, and Functions.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2017

Yin Xiangyun, Yu Haisheng, Jin Xiaoyang, Li Jingyun, Guo Hao, Shi Quanxing, Yin Zhao, Xu Yong, Wang Xuefei, Liu Rong, Wang Shouli, Zhang Liguo

Abstract excerpt

There are three major dendritic cell (DC) subsets in both humans and mice, that is, plasmacytoid DCs and two types of conventional DCs (cDCs), cDC1s and cDC2s. cDC2s are important for polarizing CD4+ naive T cells into different subsets, including Th1, Th2, Th17, Th22, and regulatory T cells. In mice, cDC2s can be further divided into phenotypically and functionally distinct subgroups. However, subsets of human...

Topics

Antigens, CD1
Blood Cells
CD5 Antigens
Cell Differentiation
Chemokine CCL21
Dendritic Cells
Glycoproteins
Humans
Immune Tolerance
Interferon Regulatory Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-10

Interleukin-4

Interleukins

Lymphocyte Activation

Phenotype

T-Lymphocytes, Helper-Inducer

T-Lymphocytes, Regulatory

Th1 Cells

Source

Open in PubMed

Identifiers

PMID: 28087664
DOI: 10.4049/jimmunol.1600193

Genes

CCL21
MAFB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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