Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetically predicted white matter microstructure mediates the relationship between risk factors and lacunar stroke.

Stroke and vascular neurology - 4 Mar 2026

Zhang Jie, Wu Min, Neville Douglas, Zou Yue, Ren Kaisi, Ye Qing, Zhong Shuchang, Xiang Haiying, Wang Wenshi, Ye Xiangming, Luo Benyan, Zhang Li

Abstract excerpt

BACKGROUND AND PURPOSE: Lacunar stroke is a complex, multifactorial disease with significant genetic underpinnings. However, the mechanisms through which genetic predispositions and risk factors contribute to its pathogenesis remain poorly understood. We investigated whether genetically predicted white matter (WM) microstructure mediates causal relationships between risk factors and lacunar stroke. METHODS: Data...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genome-Wide Association Study
Share to Hypertension

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukoencephalopathies

Share to Mendelian Randomization Analysis

Share to Predictive Value of Tests

Share to Risk Assessment

Share to Risk Factors

Share to White Matter

Source

Open in PubMed Open full text

Identifiers

PMID: 40571410
DOI: 10.1136/svn-2025-004208
PMCID: PMC13019051

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetically predicted white matter microstructure mediates the relationship between risk factors and lacunar stroke.PMID 40571410Read ↗

Genetic Architecture of Lacunar Stroke.Semantic proximity Read ↗

Genetic Associations With White Matter Hyperintensities Confer Risk of Lacunar Stroke.Semantic proximity Read ↗

Assessment of bidirectional relationships between brain imaging-derived phenotypes and stroke: a Mendelian randomization study.Semantic proximity Read ↗

Deciphering the causal relationship between blood pressure and regional white matter integrity: A two-sample Mendelian randomization study.Semantic proximity Read ↗

Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and DementiaSemantic proximity Read ↗

Genetic architecture of white matter hyperintensities differs in hypertensive and nonhypertensive ischemic stroke.Semantic proximity Read ↗

Common genetic variation influencing human white matter microstructure.Semantic proximity Read ↗

Common genetic variation influencing human white matter microstructureSemantic proximity Read ↗

Cerebral small vessel disease genomics and its implications across the lifespanSemantic proximity Read ↗

Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants.Semantic proximity Read ↗

Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies.Semantic proximity Read ↗

Genetic determinants of circulating metabolites and the risk of stroke and its subtypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.