Article
Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies.
The Lancet. Neurology - 1 May 2021
Traylor Matthew, Persyn Elodie, Tomppo Liisa, Klasson Sofia, Abedi Vida, Bakker Mark K, Torres Nuria, Li Linxin, Bell Steven, Rutten-Jacobs Loes, Tozer Daniel J, Griessenauer Christoph J, Zhang Yanfei, Pedersen Annie, Sharma Pankaj, Jimenez-Conde Jordi, Rundek Tatjana, Grewal Raji P, Lindgren Arne, Meschia James F, Salomaa Veikko, Havulinna Aki, Kourkoulis Christina, Crawford Katherine, Marini Sandro, Mitchell Braxton D, Kittner Steven J, Rosand Jonathan, Dichgans Martin, Jern Christina, Strbian Daniel, Fernandez-Cadenas Israel, Zand Ramin, Ruigrok Ynte, Rost Natalia, Lemmens Robin, Rothwell Peter M, Anderson Christopher D, Wardlaw Joanna, Lewis Cathryn M, Markus Hugh S
Abstract excerpt
BACKGROUND: The genetic basis of lacunar stroke is poorly understood, with a single locus on 16q24 identified to date. We sought to identify novel associations and provide mechanistic insights into the disease. METHODS: We did a pooled analysis of data from newly recruited patients with an MRI-confirmed diagnosis of lacunar stroke and existing genome-wide association studies (GWAS). Patients were recruited from...
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