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Article

Common genetic variation influencing human white matter microstructure.

Science (New York, N.Y.) - 18 Jun 2021

Zhao Bingxin, Li Tengfei, Yang Yue, Wang Xifeng, Luo Tianyou, Shan Yue, Zhu Ziliang, Xiong Di, Hauberg Mads E, Bendl Jaroslav, Fullard John F, Roussos Panagiotis, Li Yun, Stein Jason L, Zhu Hongtu

Abstract excerpt

Brain regions communicate with each other through tracts of myelinated axons, commonly referred to as white matter. We identified common genetic variants influencing white matter microstructure using diffusion magnetic resonance imaging of 43,802 individuals. Genome-wide association analysis identified 109 associated loci, 30 of which were detected by tract-specific functional principal components analysis. A...

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Identifiers

PMID: 34140357
DOI: 10.1126/science.abf3736
PMCID: PMC8370718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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