Article
Assessment of bidirectional relationships between brain imaging-derived phenotypes and stroke: a Mendelian randomization study.
BMC medicine - 25 Jul 2023
Yu Ke, Chen Xiao-Feng, Guo Jing, Wang Sen, Huang Xiao-Ting, Guo Yan, Dong Shan-Shan, Yang Tie-Lin
Abstract excerpt
BACKGROUND: Stroke is a major cause of mortality and long-term disability worldwide. Whether the associations between brain imaging-derived phenotypes (IDPs) and stroke are causal is uncertain. METHODS: We performed two-sample bidirectional Mendelian randomization (MR) analyses to explore the causal associations between IDPs and stroke. Summary data of 587 brain IDPs (up to 33,224 individuals) from the UK Biobank...
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