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Article

Association of cognitive reserve with the risk of dementia in the UK Biobank: role of polygenic factors.

The British journal of psychiatry : the journal of mental science - 1 Jun 2024

Yang Wenzhe, Wang Jiao, Dove Abigail, Dunk Michelle M, Qi Xiuying, Bennett David A, Xu Weili

Abstract excerpt

BACKGROUND: It remains unclear whether cognitive reserve can attenuate dementia risk among people with different genetic predispositions. AIMS: We aimed to examine the association between cognitive reserve and dementia, and further to explore whether and to what extent cognitive reserve may modify the risk effect of genetic factors on dementia. METHOD: Within the UK Biobank, 210 631 dementia-free participants...

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Identifiers

PMID: 38328972
DOI: 10.1192/bjp.2024.13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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