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Article

Analysis of IDH1 and IDH2 mutations as causes of the hypermethylator phenotype in colorectal cancer.

The Journal of pathology - 1 Sept 2025

Ward Joseph C, Morgan Melissa, Wood James, Woolley Connor, de Menezes Albert Antao Nobre, Finch Alina, Sherwood Kitty, Huang Qiwen, Henry Chloe S, Fernández-Tajes Juan, Soriano Ignacio, Thorn Steve, Legge Isabelle, McCullagh James, Kerr David, Kerr Rachel, Hejmadi Rahul K, Arends Mark J, Domingo Enric, Maughan Timothy, Bardella Chiara, Tomlinson Ian

Abstract excerpt

The CpG island methylator phenotype (CIMP) occurs in many colorectal cancers (CRCs). CIMP is closely associated with global hypermethylation and tends to occur in proximal tumours with microsatellite instability (MSI), but its origins have been obscure. A few CRCs carry oncogenic (gain-of-function) mutations in isocitrate dehydrogenase IDH1. Whilst IDH1 is an established CRC driver gene, the low frequency of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40545636
DOI: 10.1002/path.6446
PMCID: PMC12337813

Genes

IDH1
IDH2
BRAF
KRAS

Provenance

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