Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Absence of IDH mutation in colorectal cancers with microsatellite instability.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Jun 2016

Tougeron David, Guilloteau Karline, Karayan-Tapon Lucie

Abstract excerpt

BACKGROUND: Colorectal cancers (CRCs) with deficient DNA mismatch repair system (dMMR) represents approximately 12% of all CRCs. Sporadic dMMR CRCs are due to hypermethylation MLH1 gene promoter and associated with the CpG island methylator phenotype (CIMP). Isocitrate dehydrogenase (IDH) mutant tumors are associated with DNA hypermethylation in various cancers. AIMS: Look if dMMR CRC are associated with IDH...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to DNA Mismatch Repair

Share to France

Share to Isocitrate Dehydrogenase

Share to Microsatellite Instability

Share to Mutation

Source

Identifiers

PMID: 26987944
DOI: 10.1016/j.dld.2016.02.019

Genes

IDH1
IDH2
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Absence of IDH mutation in colorectal cancers with microsatellite instability.PMID 26987944Read ↗

Mismatch Repair Deficiency in Colorectal Adenocarcinoma: Clinical, Pathological and Prognostic Features, a Single Center’s Experience of 1002 CasesSemantic proximity Read ↗

Isocitrate dehydrogenase 1 R132C mutation occurs exclusively in microsatellite stable colorectal cancers with the CpG island methylator phenotype.Semantic proximity Read ↗

Microsatellite instability in colorectal cancerSemantic proximity Read ↗

Clinicopathological and molecular characterization of deficient mismatch repair colorectal cancer.Semantic proximity Read ↗

Microsatellite instability and MLH1 promoter hypermethylation in colorectal cancerSemantic proximity Read ↗

MLH1 gene promoter methylation status partially overlaps with CpG methylator phenotype (CIMP) in colorectal adenocarcinomaSemantic proximity Read ↗

Prevalence and clinicopathologic/molecular characteristics of mismatch repair-deficient colorectal cancer in the under-50-year-old Japanese population.Semantic proximity Read ↗

Analysis of mismatch repair gene mutations in Turkish HNPCC patients.Semantic proximity Read ↗

DNA mismatch repair defects: role in colorectal carcinogenesis.Semantic proximity Read ↗

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer.Semantic proximity Read ↗

Both MLH1 deficiency and BRAFV600E mutation are a unique characteristic of colorectal medullary carcinoma: An observational study.Semantic proximity Read ↗

Deficient mismatch repair system in patients with sporadic advanced colorectal cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.