Article
Isocitrate dehydrogenase 1 R132C mutation occurs exclusively in microsatellite stable colorectal cancers with the CpG island methylator phenotype.
Epigenetics - 1 Nov 2014
Whitehall V L J, Dumenil T D, McKeone D M, Bond C E, Bettington M L, Buttenshaw R L, Bowdler L, Montgomery G W, Wockner L F, Leggett B A
Abstract excerpt
The CpG Island Methylator Phenotype (CIMP) is fundamental to an important subset of colorectal cancer; however, its cause is unknown. CIMP is associated with microsatellite instability but is also found in BRAF mutant microsatellite stable cancers that are associated with poor prognosis. The isocitrate dehydrogenase 1 (IDH1) gene causes CIMP in glioma due to an activating mutation that produces the...
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