IL-17 links the tumor suppressor LKB1 to gastrointestinal inflammation and polyposis

Abstract excerpt

Mutations in the tumor suppressor liver kinase B1 (LKB1) promote the development of gastrointestinal (GI) polyps of unknown etiology. Here, we identify IL-17 as a novel driver of LKB1-dependent polyp growth. GI tumors from mice bearing heterozygous mutations in Stk11 (which encodes LKB1) display signatures of pathogenic IL-17–producing CD4 + T helper 17 (T H 17) cells. LKB1 constrains T cell inflammatory...

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