Article

Leptin receptor deficiency suppresses gastric tumorigenesis by limiting stromal activation and tumor microenvironment development.

2026-08-21

Abstract excerpt

Leptin receptor (LEPR) signaling has been implicated in multiple malignancies; however, its role in gastric tumors remains poorly defined. We previously demonstrated that mice with gastrointestinal epithelial cell-specific deletion of suppressor of cytokine signaling 3 (SOCS3 cKO), a negative feedback regulator of LEPR signaling, develop gastric tumors due to aberrant leptin production and LEPR activation. Here, w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 01ee0973-1881-5abc-8247-906cd8384e58
DOI: 10.64898/2026.08.21.746140

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leptin receptor deficiency suppresses gastric tumorigenesis by limiting stromal activation and tumor microenvironment development.DOI 10.64898/2026.08.21.746140Read

STAT3 and STAT1 mediate IL-11–dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant miceSemantic proximity Read

Acquired epithelial WNT secretion drives niche independence of developing gastric cancerSemantic proximity Read

IL-17 links the tumor suppressor LKB1 to gastrointestinal inflammation and polyposisSemantic proximity Read

Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?Semantic proximity Read

Dickkopf1 fuels inflammatory cytokine responsesSemantic proximity Read

Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical ModelSemantic proximity Read

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposisSemantic proximity Read

Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel TargetsSemantic proximity Read

Epithelial WNT secretion drives niche escape of developing gastric cancer.Semantic proximity Read

Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway.Semantic proximity Read

SOCS3Semantic proximity Read

Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells.Semantic proximity Read