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Article

Role of <i>Lkb1</i> , the causative gene of Peutz–Jegher's syndrome, in embryogenesis and polyposis

11 Jun 2002

Abstract excerpt

Peutz-Jeghers syndrome (PJS) is a dominantly inherited human disorder characterized by gastrointestinal hamartomatous polyposis and mucocutaneous melanin pigmentation. LKB1 (STK11) serine/threonine kinase is the product of the causative gene of PJS, which has been mapped to chromosome 19p13.3. However, several studies have produced results that are not consistent with a link between LKB1 gene mutation and PJS. We...

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Identifiers

PMID: 12060709
DOI: 10.1073/pnas.122254599

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