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Article

Reversibility of β-Cell-Specific Transcript Factors Expression by Long-Term Caloric Restriction in db/db Mouse.

Journal of diabetes research - 1 Jan 2016

Sheng Chunjun, Li Feng, Lin Ziwei, Zhang Manna, Yang Peng, Bu Le, Sheng Hui, Li Hong, Qu Shen

Abstract excerpt

Type 2 diabetes (T2D) is characterized by β-cell dedifferentiation, but underlying mechanisms remain unclear. The purpose of the current study was to explore the mechanisms of β-cell dedifferentiation with and without long-term control of calorie intake. We used a diabetes mouse model (db/db) to analyze the changes in the expression levels of β-cell-specific transcription factors (TFs) and functional factors with...

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Identifiers

PMID: 26998492
DOI: 10.1155/2016/6035046
PMCID: PMC4779534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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