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Clinical Significance of TP53 -Mutant Clonal Hematopoiesis Across Diseases

17 Jun 2025

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) has broad clinical relevance, and TP53 plays various roles within cells. However, the gene-specific and cross-disease significance of CHIP with TP53 mutations (TP53-CHIP) remains unclear. In this study, we evaluated TP53-CHIP using targeted sequencing data of 140,597 individuals without hematologic neoplasms in BioBank Japan. We identified 1,157 individuals...

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PMID: 40525786
DOI: 10.1158/2643-3230.bcd-24-0355

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