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Article

p53 involvement in clonal hematopoiesis of indeterminate potential

2 May 2019

Abstract excerpt

PURPOSE OF REVIEW: Clonal hematopoiesis of indeterminate potential (CHIP) increases with age and occurs when a single mutant hematopoietic stem cell (HSC) contributes to a significant clonal proportion of mature blood lineages. Somatic mutations in the TP53 gene, which encodes the tumor suppressor protein p53, rank in the top five among genes that were mutated in CHIP. This review focuses on mechanisms by which...

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PMID: 31045645
DOI: 10.1097/moh.0000000000000509

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