Article
Clonal haemopoiesis and therapy-related myeloid malignancies in elderly patients: a proof-of-concept, case-control study.
The Lancet. Oncology - 1 Jan 2017
Gillis Nancy K, Ball Markus, Zhang Qing, Ma Zhenjun, Zhao YuLong, Yoder Sean J, Balasis Maria E, Mesa Tania E, Sallman David A, Lancet Jeffrey E, Komrokji Rami S, List Alan F, McLeod Howard L, Alsina Melissa, Baz Rachid, Shain Kenneth H, Rollison Dana E, Padron Eric
Abstract excerpt
BACKGROUND: Clonal haemopoiesis of indeterminate potential (CHIP) is an age-associated genetic event linked to increased risk of primary haematological malignancies and increased all-cause mortality, but the prevalence of CHIP in patients who develop therapy-related myeloid neoplasms is unknown. We did this study to investigate whether chemotherapy-treated patients with cancer who have CHIP are at increased risk...
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