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Article

Saliva-derived DNA is suitable for the detection of clonal haematopoiesis of indeterminate potential.

Scientific reports - 14 Aug 2024

O'Reilly Robert L, Burke Jared, Harraka Philip, Yeh Paul, Howlett Kerryn, Behrouzfar Kiarash, Rewse Amanda, Tsimiklis Helen, Giles Graham G, Bubb Kristen J, Nicholls Stephen J, Milne Roger L, Southey Melissa C

Abstract excerpt

Clonal haematopoiesis of indeterminate potential (CHIP) has been associated with many adverse health outcomes. However, further research is required to understand the critical genes and pathways relevant to CHIP subtypes, evaluate how CHIP clones evolve with time, and further advance functional characterisation and therapeutic studies. Large epidemiological studies are well placed to address these questions but...

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PMID: 39143154
DOI: 10.1038/s41598-024-69398-0
PMCID: PMC11324896

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