Article

CHK1-mediated regulation of TOP1 catalytic activity suppresses replication and transcription-associated genomic instability

2024-10-25

Abstract excerpt

The Topoisomerase 1 (TOP1) catalytic cycle involves a TOP1-DNA-covalent-complex (TOP1cc), which, if stabilized, can induce rapid accumulation of potentially lethal DNA double strand breaks (DSBs). Although TOP1cc are critically associated with genome instability, it is not yet precisely known how cells regulate TOP1cc level, under unperturbed physiological-condition, to prevent its accumulation and lethal conseque...

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Literature Corpus work: 6b8cfdc9-ce0a-5c09-96a3-4b123cef3069
DOI: 10.1101/2024.10.23.619942

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