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Article

Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies

1 May 2021

Abstract excerpt

An effective HIV-1 vaccine will likely need to elicit broadly neutralizing antibodies (bNAbs). Broad and potent VRC01-class bNAbs have been isolated from multiple infected individuals, suggesting that they could be reproducibly elicited by vaccination. Several HIV-1 envelope-derived germline-targeting immunogens have been designed to engage naive VRC01-class precursor B cells. However, they also present...

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PMID: 33951425
DOI: 10.1016/j.celrep.2021.109084

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