Article
Next generation sequencing analysis reveals complex genetic architecture of childhood-onset systemic lupus erythematosus.
Lupus science & medicine - 10 Jun 2025
Lewandowski Laura, Hiraki Linda, Scott Christiaan, Barrera-Vargas Ana, Romo Tena Jorge, Gómez-Martín Diana, Ombrello Michael J, Aksentijevich Ivona, Deng Zuoming, Musolf Anthony M, Paul Subrata, Lu Shajia, Gadina Massimo, Hupalo Daniel, Dalgard Clifton L, Hasni Sarfaraz, Silverman Earl D, Kaplan Mariana J
Abstract excerpt
OBJECTIVES: Our current understanding of the genetic architecture of childhood-onset SLE (cSLE) is limited by a dearth of comprehensive genomic studies in cSLE. We have quantified the number of known rare and common SLE risk variants in a diverse cSLE cohort. We characterised type I interferon (IFN) gene expression scores along with genomic data. METHODS: We performed whole genome sequencing on 83 patients with...
Read the complete abstract on PubMedTopics
- Humans
- Lupus Erythematosus, Systemic
- Child
- Female
- Male