Trio Whole Exome Sequencing in Chinese Childhood‐Onset Lupus Reveals Novel Candidate Genes

Abstract excerpt

OBJECTIVE: Systemic lupus erythematosus (SLE) is an autoimmune disease in which rare and common gene variants contribute to pathogenesis. Severe sporadic disease in children is often explained by "de novo" variants that can be uncovered by trio sequencing. METHODS: Whole-exome sequencing was performed in 50 Chinese trios with childhood-onset SLE (cSLE). Rare coding variants in SLE-associated genes and all de novo...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genomics and Rare Diseases
• Share to Systemic Lupus Erythematosus Research
• Share to T-cell and B-cell Immunology