Article
Genetic determinants of childhood onset systemic lupus erythematosus.
Lupus science & medicine - 23 Jun 2026
Nelson Meghan, Murthy Shanta, Maddipatla Sushma, Shenoy Sreekala, Ponder Lori, Chandrakasan Shanmuganathan, Kugathasan Subra, Cutler Dave, Prahalad Sampath
Abstract excerpt
INTRODUCTION: Childhood-onset systemic lupus erythematosus (cSLE) is associated with significant morbidity and mortality. While numerous variants have been associated with adult-onset SLE, limited data exist on genetic variation within cSLE. We aimed to investigate genetic factors of early-onset cSLE, defined as onset of cSLE prior to age 10. METHODS: Employing a case-only design, we performed whole genome...
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