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IFN-I Score and Rare Genetic Variants in Children with Systemic Lupus Erythematosus

3 Jun 2024

Abstract excerpt

Introduction: Interferon I (IFN I) signaling hyperactivation is considered one of the most important pathogenetic mechanisms in systemic lupus erythematosus (SLE). Early manifestation and more severe SLE courses in children suggest a stronger genetic influence in childhood-onset SLE (cSLE). Aim: To evaluate IFN-I score and SLE-associated genetic variants in cSLE. Material and Methods: 80 patients with cSLE were...

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PMID: 38927451
DOI: 10.3390/biomedicines12061244

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