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Counteracting CAR T cell dysfunction

9 Nov 2020

Abstract excerpt

In spite of high rates of complete remission following chimeric antigen receptor (CAR) T cell therapy, the efficacy of this approach is limited by generation of dysfunctional CAR T cells in vivo, conceivably induced by immunosuppressive tumor microenvironment (TME) and excessive antigen exposure. Exhaustion and senescence are two critical dysfunctional states that impose a pivotal hurdle for successful CAR T cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33168929
DOI: 10.1038/s41388-020-01501-x

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