Article

Targeting CAR-T cell senescence through Mysm1-SSBP1 axis improves persistence and therapeutic efficacy

2025-07-08

Abstract excerpt

<title>Abstract</title> <p>Chimeric antigen receptor (CAR)-T cell immunotherapy has demonstrated remarkable success in treating hematological malignancies, yet its clinical efficacy remains limited, particularly against solid tumors. Emerging evidence implicates T cell senescence as a key immunosuppressive barrier in cancer immunotherapy. In this study, we engineered Mysm1-overexpressing CAR-T cells and identifie...

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Literature Corpus work: d6a1a9e0-b637-5502-add0-6f8ae8927000
DOI: 10.21203/rs.3.rs-6947364/v1

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